Hello everyone and welcome to my 228th analysis, this time featuring Cain.
Overview: The first ever Elite monster is a truly fearsome attacker. Access to Bleed Hater as part of his trait, in addition to 3 moves that apply Bleeding to an enemy and give Cain an extra turn make him have an explosive damage output, and access to heals and Evasion makes him a tough monster to break. Cain's Life, above 40k, is also a very solid Life stat that complements his bruiser-ish side. Abomination is a good trait to combat Saulot or any other Possession monster for that matter, and blocking Bleeding allows him to not die too quickly against opposing Cain while blocking Nightmares is good overall. He could have used a better Speed tier, but there is still no denying how dangerous Cain can be.

-Shadow Wanderer
-Ancestral Bite
-Soul Rip
-Instant Rest/Quick Bite/Deadly Stigma
Runes: 2 Strength 1 Speed/1 Strength 1 Speed 1 Life
Mutant Rune options: Strength&Life, Speed&Life, Life&Strength
Relics: Swords and Essences

Build Explanation:
Shadow Wanderer's Evasion allows Cain to use it very effectively as a hit-and-run skill, especially with some of the upcoming moves. Ancestral Bite is a nuke with 70 Base Power and 100% Life Steal, which is good to eliminate monsters quickly while keeping Cain alive. Soul Rip is Cain's second strongest attack, and it applies Bleeding to the target while giving him an extra turn - this in conjunction with either of the former 2 moves on a monster will probably kill it if the target doesn't have Life Runes. Lastly, Instant Rest cleans all debuffs on Cain while giving him Regeneration, Stamina Regeneration and Damage Boost - this is useful if the enemy frequently applies debuffs. Otherwise, either of his other 2 Bleeding + extra turn moves are better here, since they allow Cain to do even more damage to a single target or to kill a monster with the combination of that move + Soul Rip, allowing him to not lose the turn after killing his target.
2 Strength 1 Speed with Life Mutations is standard on attackers, but Cain can perform well with a rainbow spread too, since Ancestral Bite will probably bring him back to full after using it on a Bleeding monster, plus the damage boost from Bleed Hater will still do very high damage.

-Quick Bite
-Deadly Stigma
-Soul Rip
Runes: 3 Strength
Mutant Rune options: Strength&Stamina, Strength&Life
Build Explanation:
As the name implies, this build aims to cheese wins with Bleed Hater. The plan is to use your Bleeding + extra turn moves on all 3 opponents, then using Stigmata to finish them off, given that it will essentially be a Triple Damage boosted base 30 AOE on enemies that were already damaged. However, there are a few things to note before trying to use this:
-No more than 1 enemy must be immune to Bleeding, or you won't kill the majority of the enemy team.
-No Anticipation monsters must be present, or their Trait must be disabled, since they will interrupt Cain's combo very easily.
-No Taunt/Mega Taunt must be present on the enemy team for obvious reasons. Same thing with Evasion or any of the Phobic Shields.
-You won't be killing Dodge Area monsters with this. Instead, try killing their other 2 teammates.
In choosing your 2 other teammates, you can use monsters that apply Special Weakness to enemies, like Samael or Llum, since Stigmata's power is lacking. Depending on the situation, you may not need to use your moves in the way I told you to: know that almost no monster in the game can survive 3 of this Cain's hits, let alone 4, and the average monster dies to the combo of any Bleeding move + Soul Rip. You can kill an important enemy instead of targeting the whole enemy team if that gives you a better advantage.
3 Strength is necessary here to compensate for the low Base Powers of the moves you'll be using, and you need the highest chances of success on a set like this. Mutations are the same.

Teammate Options: Monsters that can apply Bleeding are very good with Cain. Zeighar is a good denier on a team with him, since he'll apply Bleeding to all enemies before Cain even moves, which will significantly increase his damage output. For more Teammate options, check out this article.

Countering Cain: Removing his Bleeding from your team is the best way to deal with Cain. Being immune to said debuff i the first place is even more useful. For more Counter options, check out this article.