To start with it is my hope that this will not become a common thing. Even with auto battle speed up the fights take way too long. Maybe multiple amounts of time compared to before.
So the exhausting mask things that literally take all or nearly all your stamina and the ones that heal more than 15k damage are seriously game changers. As in they make more difference than runes. I thought it was said that relics were not going to be must haves...that dictate the battle. Both of these are prime examples from the talos dungeon lv 2. I have not encountered these in pvp or tw yet, but I imagine they are there too.