So my Zyla had the usual rune setup (strength, speed, stamina), but I got her a Charging Banner. So I decided to swap the stamina rune for another strength rune. Does she need the stamina rune with this relic?
Right now she's rank 3 and one-shotted a rank 5 Thetys, but she runs out of stamina way quicker (the relic is lvl 20 and I'm going to make it lvl 35).
By the way all of the runes are lvl 10.

Mine wears 3 team speed, a Charging Banner, and a Jakugan Sword, and she sweeps just fine.

@C0ntr1v3d unfortunately I don't have that sword

@Keki14, I did the same on my Zyla, when I had tough time against Faraday in Nemesis dungeons. Have been running happily since.

Rank 3 would be more challenging when facing all rank 5 team, whose health is big enough for your stamina to run out, especially with some relics.

@SkeelMaster that's why I avoid them if I can (but of course it's not easy in L4 )