Similar to elemntium, you can use these runes to act as either a gold, stamina, speed, strength or a life rune whilst crafting. After the crafting process is finished, you will loose the orb. Orbs are rarer than elemntium, as having 67 (like I have right now) might be classed as OP.
You could gain these orbs from events, rune dungeons, or rarely PVP and adventure map wheels. Wheels must be level 200+ on the adventure map to have orbs on them, PVP is just by chance.